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Cisplatin (Cistero) is a platinum-based chemotherapy drug used to treat various cancers by interfering with DNA replication. 

Cisplatin binds to DNA, forming cross-links that stop cells from dividing. This process triggers programmed cell death (apoptosis), primarily affecting rapidly dividing cancer cells. 

Cisplatin is designed to target tumors with fast cell growth, including cancers that often require aggressive treatment, such as ovarian, lung, bladder, and testicular cancers. By preventing proper DNA repair, Cisplatin leads to the destruction of these malignant cells. 

It is important to understand that Cisplatin (Cistero) can also affect healthy cells that divide quickly, such as those in the bone marrow, gastrointestinal tract, and hair follicles. This action can lead to side effects like nausea, fatigue, and hair loss. Patients receiving Cisplatin (Cistero) typically undergo regular monitoring to manage these potential side effects effectively. 

Cisplatin Usage

Cisplatin (Cistero) is primarily used for treating cancers that are resistant to other chemotherapy agents, including ovarian, lung, bladder, and testicular cancers:

• Ovarian Cancer: Cisplatin is effective in treating advanced or recurrent ovarian cancer by disrupting the DNA of cancer cells, halting their division and growth. When combined with paclitaxel, Cisplatin enhances treatment efficacy, reduces tumor size, and improves survival rates by targeting multiple pathways involved in cancer cell proliferation. This combination therapy also aids in managing recurrences, increasing the chances for long-term remission.

• Lung Cancer: Cisplatin serves as a cornerstone in treating non-small cell lung cancer (NSCLC) by binding to DNA, disrupting replication, and leading to cell death. It is commonly paired with gemcitabine or vinorelbine, which target different mechanisms of tumor growth and resistance. This multidrug approach improves treatment outcomes and increases overall survival rates for patients with this aggressive cancer.

• Testicular Cancer: Cisplatin has revolutionized the treatment of testicular cancer, significantly improving survival rates by forming DNA adducts that block cancer cell replication. Administered in combination with etoposide and bleomycin in the BEP regimen, this approach achieves high cure rates, even in advanced cases, making it a standard treatment for this malignancy.

• Bladder Cancer: Cisplatin is effective for advanced or even metastatic bladder cancer by disrupting the DNA of cancer cells, preventing their growth and replication. It is used for systemic treatment and to shrink tumors prior to surgery, enhancing the feasibility of surgical interventions. This reduction in tumor burden increases the likelihood of successful surgical outcomes and improves overall patient prognosis.

Dosage

Cisplatin (Cistero) is administered intravenously. Dosages depend on body surface area (BSA) and kidney function. Typical doses range from 20 to 100 mg/m² per cycle, with treatment cycles repeated every 3 to 4 weeks. Pre-treatment hydration helps protect the kidneys from damage. Kidney function is closely monitored, and blood tests are done before each cycle to ensure patient safety.

Cisplatin Side Effects

This medication also includes the following side effects:

• Peripheral Neuropathy: Cisplatin disrupts peripheral nerve function by damaging mitochondrial activity in nerve cells. This results in numbness, tingling, and chronic pain, primarily in the extremities.

• Bone Marrow Suppression: Cisplatin inhibits bone marrow activity, leading to reduced production of white blood cells, red blood cells, and platelets. This increases infection risk and bleeding tendencies, requiring frequent blood tests.

• Nausea and Vomiting: Cisplatin stimulates the brain’s chemoreceptor trigger zone, inducing severe nausea and vomiting. Antiemetic drugs are essential to manage this, but prolonged vomiting can lead to dehydration.

• Cardiovascular Effects: Cisplatin can lead to cardiovascular complications, including irregular heart rhythms and increased blood pressure. This occurs due to direct effects on cardiac cells and electrolyte imbalances, necessitating monitoring for patients with pre-existing heart conditions.

• Vision Changes: Some patients report vision changes, such as blurred vision or altered color perception. Cisplatin can affect the optic nerve or retinal cells, leading to these symptoms. Immediate consultation with an eye specialist is recommended if vision changes occur.

• Gastrointestinal Issues: Cisplatin can cause gastrointestinal side effects, including diarrhea, constipation, and abdominal pain. These arise from the drug's effects on rapidly dividing cells in the gastrointestinal tract, disrupting normal function.

• Changes in Taste: Cisplatin can alter taste perception, leading to a metallic taste or aversion to certain foods. This occurs due to its impact on taste buds and oral mucosa, affecting appetite and nutrition during treatment.

Cisplatin Price and Availability

Cisplatin’s cost arises from various factors, primarily its platinum content, complex refinement processes, and strict quality controls during production. Platinum is a rare metal that requires extensive extraction and purification, contributing to high costs. 

Additionally, manufacturing Cisplatin involves multiple steps, including synthesis, formulation, and thorough testing to ensure safety and effectiveness. These steps demand specialized facilities and adherence to regulatory standards, which increases expenses. 

The price of Cisplatin in the Philippines and Malaysia are high because of such factors, so it’s pricier than other chemotherapy drugs. 

However, generic Indian medicine offers more affordable alternatives, improving access to treatment for patients in regions with limited healthcare resources. If you are Interested in buying this medicine then you can make an inquiry with us & we will get back to you with best price.

Cisplatin Safety Advice

Alcohol

Avoid alcohol during treatment, as it exacerbates dehydration and increases strain on the kidneys, reducing their ability to filter Cisplatin effectively. Discuss alcohol intake with your doctor for individualized advice.

Pregnancy

According to multiple studies and tests on animals, Cisplatin is highly teratogenic, posing severe harm to a fetus. Women must avoid pregnancy during and after treatment by using reliable contraception, as advised by their doctor. Any unplanned pregnancy should be reported immediately.

Breastfeeding

Cisplatin passes into breast milk (especially further into chemotherapy) and can harm a nursing infant. Breastfeeding should be discontinued while receiving treatment. Consult your doctor for guidance on alternatives or when it might be safe to resume breastfeeding.

Driving

Cisplatin may cause fatigue, neuropathy, and dizziness, which can impair your ability to drive or operate machinery. If you experience these symptoms, refrain from driving until you feel fully alert and functional.

Liver

Cisplatin may cause liver enzyme elevations and hepatic stress. Routine liver function tests are essential. Discuss any existing liver conditions with your oncologist to determine appropriate dosing or alternative therapies.

Doctor Advice

While receiving Cisplatin, you need close supervision from your doctor. They will monitor your kidney function and blood counts, adjusting treatment duration based on your response. Report any side effects, like nausea or unusual bruising, promptly. This helps your doctor tailor your treatment plan effectively for optimal outcomes.