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Lenvatinib is a newer targeted drug that helps prevent the growth of cancer cells, and the development of blood vessels supplying the cancerous tumors. Lenvatinib is a seldom prescribed anticancer drug that belongs to the range of clinical drug categories referred to as tyrosine kinase inhibitors (TKIs). In contrast to traditional chemotherapy produced by bombarding the organism with a chaotic fire and killing rapidly dividing cells, Lenvatinib destroys the proteins used by tumors to proliferate and metastasize.
It acts through the inhibition of many receptor tyrosine kinases (RTKs), such as:
Vascular Endothelial Growth Factor Receptors (VEGFR 1-3): also plays a major role in formation of new blood vessels (angiogenesis).
Fibroblast Growth Factor Receptors (FGFR 1 4 ): ensure the growth of tumor cells and revitalization of the tissues.
Platelet-Derived Growth Factor Receptor alpha (PDGFRalpha): promotes the survival of cancer cells, and development of tumor stroma.
Proto-oncogenes KIT and RET, linked with the promotion of tumors.
Listed among these targets, Lenvatinib interferes and prevents the cancer from further growth as well as cuts down the blood supply of the tumor, which renders it mortified and exposed to attack.
Differentiated Thyroid Cancer (DTC) that has become advanced even after administration of radioactive iodine.
Hepatocellular Carcinoma (HCC) among patients who have never had a systemic treatment.
The cancer is Renal Cell Carcinoma (RCC), and is used in first-line treatment or after therapy in combination with pembrolizumab (RCC), or everolimus (patients after treatment).
Research about the possible application of Lenvatinib on other cancers including endometrial cancer and non-small cell lung cancer (NSCLC) is also undergoing research.
Lenvatinib is used depending on cancer type, intake of body weight and tolerance of patients. It can only be used with close guidance of an oncologist.
Differentiated Thyroid Cancer (DTC):
24 mg orally (two 10 mg + one 4 mg capsule) once a day until progression or intolerable side effects in a constant cycle of 28 days.
Hepatocellular Carcinoma (HCC:
60 kg: 12 mg by mouth once a day.
8 mg/day: 60 kg orally once/day.
Everolimus (Renal cell carcinoma(RCC):
Lenvatinib 18 mg po qd + everolimus 5 mg po qd.
Guidelines:
It may be taken and not taken with food,
Capsules are to be taken up with water.
When one forgets to take a dose, say during 12 hours of another dose, then take no more, skip the dose.
When the patient has not been able to swallow, they can be allowed to dispense the contents of the capsule into water or apple juice under particular pharmacist directions.
Due to the action of Lenvatinib in multiple pathways, it may produce a vast number of side effects that may be mild or serious.
Common Side Effects (30% patients):
Hypertension:usually it manifests itself early; it is necessary to monitor BP regularly.
Diarrhea :can result in dehydration when left unattended to.
A loss of appetite and weight.
Weakness or fatigue: can be experienced in day-to-day activities.
Vomiting and nausea.
Proteinuria:This is identified by a urine-related test.
Pain in joints or in muscles.
Changes on skin including redness or peeling on hands/feet.
Dizziness and headache.
Thyroid hormone low levels (hypothyroidism).
Serious Side Effects
Heart issues that include heart failure and irregular heart beat.
Severe hemorrhage, or bleeding.
Symptoms of liver failure: yellow skin/eyes and dark urine.
Signs of kidney failure: inflammation, low urine.
Brain-inflammation (posterior reversible encephalopathy syndrome - PRES).
To create a perforation of the GI tract or a fistula.
Management Tips:
Report symptoms early to get adjustment of doses.
GI upset and fatigue can be lessened through hydration and a normal diet.
During the initial 2 months biweekly monitoring of blood pressure is necessary.
Lenvatinib is marketed globally under brand name as Lenvima, and branded form can be costly, particularly in long-term treatment. Considerably more patients now use high-quality generic Lenvatinib that is as effective but significantly cheaper.
In India, generic versions of Lenvatinib are available at very affordable prices. It can be purchased 80% below the branded alternatives. We obtain genuine, certified generics, produced by licensed pharmaceutical manufactures and can easily export them all over the world. This ensures patients can buy Lenvatinib online from us with confidence, knowing they are getting genuine medication at the best price.This will guarantee the patients access the Lenvatinib through us without any fear that they are purchasing a fake drug at a higher price.
Our site has a competitive price, discreet packaging, a stable delivery process, and bulk purchase opportunities to patients needing prolonged treatment. Availability is also predictable and you do not need to go through treatment interruptions. If you are interested to buy online lenvatinib then send us WhatsApp message now or fill the Ask price form & we will get back to you with the discounted price.
Alcohol
Do not take alcohol; it may worsen some of the side effects of Lenvatinib as well as raise the chances of liver damage.
Pregnancy
Not safe during pregnancy; can damage an unborn baby. Employ good contraception throughout the treatment, and 30 days afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and within at least 1 week of the final dose; the drug can enter into breast milk.
Driving
Do not drive and rather avoid challenging machine-related jobs when dizziness, subdued, and vice versa when you are on Lenvatinib.
Liver
Periodic checking is needed when it comes to normal functioning of the liver; dosage correction may be essential in the event of liver damage.
Doctor Advice
Use with care, only under specialist supervision production; report any weird feeling or side effects promptly.
Warnings
Reference
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