It is a standard medicine for prostate cancer treatment. It is marketed by the name "Zytiga." as an oral pill.
The prostate is the gland around the urethra in the male reproductive system. Testosterone is the natural male hormone that propagates the growth of prostate cancer. Common symptoms of cancer include difficulty in urination, blood in the urine, pelvic pain, etc. Abiraterone inhibits the production of the hormone and slows the spread of prostate cancer. Ideally, you can pair the drug with a corticosteroid (like prednisone). It can treat metastatic castration-resistant prostate cancer and metastatic high-risk castration sensitive prostate cancer. The treatment is practically a form of hormone therapy. It goes for the class of anti-androgens.
Hormones are chemical substances that affect the tissues and are formed in glands. Our body hosts various hormones for different purposes. Hormone therapy works by altering or stopping the production of a specific hormone. It works well against cancer by observing how receptors for particular hormones can treat tumor cells by growing on the surface. Decreasing hormone production helps fight prostate cancer. Metastatic tumors can produce testosterone on their own. Androgen deprivation therapies focus on reducing the androgens levels produced by the testicles and not the adrenal glands. Abiraterone works slightly differently.
The drug treatment restricts the enzyme required in hormone production. As a result, it affects the adrenal and testosterone levels. Abiraterone Acetate seizes androgen production at the testes, adrenal glands, and the tumors as well. Hence, the treatment is far more comprehensive.
If the drugs seem useful in the treatment, physicians are known to expand its use for other cures.
Keep the medicines away from minors and pets. The drug stayed best at room temperature and tucked away in a cool, dry place. Also, avoid storing it in your bathroom due to the high moisture content in the air. Discard the drugs responsibly. Do not dump them in the drain or flush them down the toilet. Contact local waste disposal to ensure proper the medication gets appropriately discarded.
Abiraterone Acetate (Zytiga) is generally prescribed once a day. Usually, physicians recommend an empty stomach; say two hours after a meal or an hour before. For best results, take the pill at the same time every day. Also, take 10mg Prednisone daily along with the drug. It is advisable to consult your physician regarding the dosage as it depends on a myriad of factors. A lot of consideration goes into your schedule and duration of effective treatment.
Periodic laboratory tests such as blood pressure and potassium levels, liver function, PSA assess your bodily functions and the effect of the drug on it. The results also indicate the onset of side effects. Your doctor can also evaluate your progress better with a healthy, regular dose of Abiraterone Acetate and medical tests.
In case of overdose:
It is best to avoid double doses to compensate for a missed dose strictly. If the situation occurs, do not worry about your miss and ensure the next dose is taken at your regular time. Consult your doctor immediately in case you miss repeated doses.
Side effects accompany most cancer treatment medicines, and Abiraterone Acetate is not an exception. However, the side effects vary from patient to patient. The treatment for any side effects can be calculated in terms of onset, duration, and severity. They are also temporary and subside once the treatment is over. Abiraterone Acetate side effects are predictable and manageable. With caution and planned treatment, the consequences can also be mitigated and even prevented.
Here are some of the more common side effects experienced by more than 30% of patients –
Some of the other, less common symptoms include –
Allergic reactions arising from the drug are uncommon. However, do not neglect any signs of rashes, itching, dizziness, or breathing troubles. The drugs restrict enzymes in the adrenal glands, leading to increased mineral corticosteroid production, leading to some of the mentioned side effects. Dosage of prednisone counters the impact generally.
While it may seem like a lot of side effects, doctors prescribe Abiraterone Acetate as the benefits outweigh the consequences. Moreover, the occurrence of side effects is rare. Patients with a history of cardiovascular trouble need to be closely monitored. Regulate your blood pressure levels throughout the treatment. If you experience any uncanny symptoms, consult your physician immediately.
During the treatment, it is vital to cooperate with your physician regarding any symptoms. Do not take side effects or changes to your body lightly. In case you observe any of the following signs, call an emergency with your doctor –
-High fever (greater than 100.4°F)
-Chest pain or heartburn
-Inability to urinate (for over eight hours)
While these symptoms are critical, you should also seek medical attention for the following signs –
The drug can cause QT prolongation, which is an increased or irregular heartbeat. Patients with a medical history of heart troubles are more susceptible. Inform your doctors if you or your family has had heart failures, slow heartbeats, cardiac arrests, etc. Low potassium or magnesium levels also make you vulnerable to QT prolongations. Diuretics or water pills also increase the risk. Older adults should be wary of the conditions.
The prolonged use of corticosteroid medications can inhibit the effects of abiraterone. The body does not respond well to physical stress. If you are scheduled for an emergency operation or dental treatment, notify the doctor or dentist regarding medication usage within the last twelve months. Also, discuss with your doctor if you experience fatigue, weight loss, sweating, diarrhea, vomiting, etc.
Now it is clear; the treatment requires transparency from your end and precautions. Before initiating the treatment, inform your doctor about allergic reactions, previous heart problems, liver problems, and blood pressure levels. Abiraterone Acetate contains inactive ingredients that can trigger allergies.
Also, inform your doctor regarding the other medications you might be taking at the time. It includes vitamins, herbal remedies, and prescribed drugs. Here are some things to avoid during the treatment –
Concisely, here are some points about how you can help yourself make the treatment more effective –
Regular check-ups and lab tests help evaluate your progress and decide on future actions. Periodic blood tests can give an idea about your blood count (CBC) and vital organ functions. Your healthcare team operates on the information gathered from the tests.
Abiraterone Acetate is the generic name of Zytiga. The FDA approves it, yet subject to drug patents and exclusivity. The approved Zytiga formulation is –
- Manufacturer: JANSSEN BIOTECH
Approval date: April 28, 2011
- Manufacturer: JANSSEN BIOTECH
Approval date: April 14, 2017
Some generic versions of abiraterone acetate are available in India which is very affordable and same effective as Zytiga. Here are some listings for your perusal –
- Brand: Abirapro
- Packaging Size: 120 pills
- Manufactured by: Glenmark Pharmaceuticals Ltd.
- Composition: Abiraterone acetate 250mg
- Brand: Xbira
- Packaging Size: 120 pills
- Manufactured by: Cipla Ltd.
- Composition: Abiraterone acetate 250 mg
-Packaging Size: 120 pills
-Manufactured by:- Sun Pharmaceutical Industries Ltd.
-Composition: Abiraterone acetate 250 mg
Cost of Zytiga (Abiraterone)
The cost of Zytiga is around $5000 for 120 tablets. It depends on country & pharmacies you visit. However, generic abiraterone acetate cost only 4% of Zytiga. For more information about cost please send enquiry to us via WhatsApp +91-9911944593 or E-mail at email@example.com.
However, the intention of the information provided is purely educational. Regarding cancer treatment and medication, always start to consult a specialist. Read the information pamphlets and clarify everything with your doctor. Also, refrain from recommending the drug to another patient even if it shows positive results in your treatment. The side effects and course of action depends on the conditions of each patient.
Drug interaction predictions are not always accurate as the medication can increase side effects as the treatment progresses. Maintain a list of all the medicines you consume. Document the treatment and retain all prescriptions, nonprescription drugs, and herbal remedies. Share the information with healthcare experts. Therefore, it is best to stick to the prescribed dosage and not make any brave alterations on your own. For best results, cooperate with your healthcare team and abide by the treatment procedure.
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